Zhenghuai Tan Selected Research

Scopolamine (Hyoscine)

2/2022	Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease.
5/2020	Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.
1/2020	Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.
9/2019	Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
1/2019	Design, Synthesis, and Evaluation of Novel Ferulic Acid Derivatives as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease.
7/2017	Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.
4/2017	Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
4/2015	Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.
2/2015	Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
4/2014	Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.

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Zhenghuai Tan Research Topics

Disease

28	Alzheimer Disease (Alzheimer's Disease) 12/2022 - 04/2014
6	Memory Disorders (Memory Loss) 01/2020 - 04/2014
4	Cognitive Dysfunction 02/2022 - 02/2015
1	Neuroinflammatory Diseases 02/2022
1	Parkinson Disease (Parkinson's Disease) 01/2022
1	Fatty Liver 08/2020
1	Necrosis 08/2020
1	Tuberculosis (Tuberculoses) 08/2020
1	Dyskinesias (Dyskinesia) 01/2019
1	Vascular System Injuries 01/2019
1	Atherosclerosis 10/2011
1	Diabetes Complications 07/2008
1	Diabetic Nephropathies (Diabetic Nephropathy) 07/2008

Drug/Important Bio-Agent (IBA)

10	Scopolamine (Hyoscine)FDA Link 02/2022 - 04/2014
10	LigandsIBA 02/2022 - 02/2015
5	AntioxidantsIBA 02/2022 - 02/2015
5	Biological ProductsIBA 05/2020 - 01/2019
4	Mannich BasesIBA 01/2021 - 01/2017
4	Amyloid (Amyloid Fibrils)IBA 01/2018 - 04/2016
3	Chalcone (Benzalacetophenone)IBA 04/2021 - 09/2019
3	AcetylcholinesteraseIBA 01/2018 - 01/2017
3	scutellareinIBA 07/2017 - 02/2015
2	Cholinergic Agents (Cholinergics)IBA 02/2022 - 02/2015
2	Monoamine Oxidase (MAO)IBA 01/2022 - 01/2017
2	GenisteinIBA 01/2021 - 04/2014
2	Rivastigmine (Exelon)FDA LinkGeneric 02/2020 - 02/2015
2	Flurbiprofen (Froben)FDA LinkGeneric 01/2020 - 01/2019
2	CarbamatesIBA 09/2019 - 02/2015
2	ferulic acid (sodium ferulate)IBA 01/2019 - 04/2017
2	Neuroprotective AgentsIBA 01/2019 - 02/2015
2	Oxidoreductases (Dehydrogenase)IBA 01/2018 - 01/2017
2	pterostilbeneIBA 01/2018 - 04/2016
2	auroneIBA 01/2017 - 01/2016
1	naringeninIBA 12/2022
1	6- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA 02/2022
1	Chelating AgentsIBA 02/2022
1	cinnamic acidIBA 01/2021
1	CholesterolIBA 08/2020
1	Transaminases (Aminotransferases)IBA 08/2020
1	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 08/2020
1	Pyrazinamide FDA LinkGeneric 08/2020
1	Messenger RNA (mRNA)IBA 08/2020
1	Rifampin (Rifampicin)FDA LinkGeneric 08/2020
1	Proteins (Proteins, Gene)FDA Link 08/2020
1	Sterol Regulatory Element Binding Protein 1IBA 08/2020
1	ApigeninIBA 02/2020
1	AminesIBA 01/2020
1	Clioquinol (Vioform)FDA Link 01/2020
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2020
1	phthalideIBA 01/2020
1	Pharmaceutical PreparationsIBA 01/2019
1	salicylamideIBA 01/2019
1	thioxanthoneIBA 01/2017
1	Pyridoxine (Pyridoxin)FDA LinkGeneric 01/2017
1	MetalsIBA 01/2017
1	ResveratrolIBA 01/2017
1	Cholinesterases (Cholinesterase)IBA 04/2016
1	scutellarinIBA 02/2015
1	Trace Elements (Biometals)IBA 02/2015
1	CarbonIBA 04/2014
1	SaponinsIBA 10/2011
1	ZymosanIBA 10/2011
1	IntegrinsIBA 10/2011
1	salvianolic acid BIBA 07/2008
1	Glucose (Dextrose)FDA LinkGeneric 07/2008
1	NF-kappa B (NF-kB)IBA 07/2008

Therapy/Procedure

1	Therapeutics 01/2020